PMID

Data

Article Title

Organization

Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.

University of Massachusetts Medical School

Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.

Glsynthesis

Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity.

University of Ferrara

Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.

Katholieke Universiteit Leuven

N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase.

Istituto Di Genetica Biochimica Ed Evoluzionistica

Species- or isozyme-specific enzyme inhibitors. 6. Synthesis and evaluation of two-substrate condensation products as inhibitors of hexokinases and thymidine kinases.

TBA

Species- or isozyme-specific enzyme inhibitors. 5. Differential effects of thymidine substituents on affinity for rat thymidine kinase isozymes.

TBA

Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.

Universit£

Design, synthesis and biological evaluation of 2'-deoxy-2',2'-difluoro-5-halouridine phosphoramidate ProTides.

Cardiff University

3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.

Swedish University Agricultural Sciences

3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase.

Ghent University

Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteria.

University of Copenhagen

Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.

Brigham Young University

Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging.

Katholieke Universiteit Leuven

Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography.

Ku Leuven

N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.

Instituto De QuíMica MéDica (Csic)

Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase.

Roche Discovery Welwyn

Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.

University of Massachusetts Medical School

Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.

Academy of Sciences of The Czech Republic

Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.

University of Massachusetts Medical School

Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo.

Glsynthesis